The UK legislation for the safety and quality of blood, organs, tissue and cells (including reproductive cells) is based on EU law. The European Union Withdrawal Act 2018 ensures that EU-derived domestic legislation will continue to have effect after the end of the transition period. In 2019, regulations were introduced to ensure that UK legislation in this area could function effectively after the transition period. However, Northern Ireland will remain subject to relevant EU laws as a result of the Ireland/Northern Ireland Protocol. This article looks at four statutory instruments that would amend the 2019 regulations and enable Northern Ireland to continue to meet EU law.